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Bone health

These pages are about bone health and epilepsy in the UK. If you are looking for information about bone health and epilepsy in another country, please contact your local epilepsy organisation.

In this section


Studies suggest that people who take epilepsy medicines for a long time are at higher risk of thinning and breaking of bones than people who don’t take epilepsy medicines. Bone health and epilepsy looks at some of these studies. It gives some tips to protect bone health and tells you where to go for more information.

Epilepsy Action has more information about epilepsy medicines.

How our bones grow and repair

Bones are live tissue and our bones are constantly renewing themselves by two processes. One is called resorption, the other is called formation. Resorption is when old bone is removed through the bloodstream. Formation is when new bone is formed. The end result keeps our bones as strong as possible, and makes sure that any damaged bone is replaced.

Ideally, bone resorption and formation should match each other, so that the amount of bone removed always equals the amount of new bone formed. However, this changes throughout life; for example resorption often exceeds formation as we grow older. This balance is made possible by various hormones in our bodies, including vitamin D. Vitamin D is needed by the body to absorb calcium. Calcium is essential for healthy bones.

Vitamin D is mainly produced in the body through exposure to sunlight. It is estimated that we need about 45 minutes of exposure (bare arms, head and neck) each week. This is often difficult in the UK and therefore maintaining good vitamin D levels requires supplementation.

Bone mineral density

Bone mineral density (BMD) is a measure that shows the strength of our bones at a given time.  Between childhood and the age of 20 – 25 years, our bones increase in density and become stronger, bigger and heavier. This is possible by an ongoing process of growth and repair. They then stabilise until we reach middle-age, when they gradually lose strength. The stronger bones are, the less likely they are to break. 

People at risk of low bone mineral density

Some people have a low BMD. If you have a low BMD this may cause a condition called osteoporosis. Osteoporosis affects the bones, causing them to become weak and fragile and more likely to break.

Below are some possible causes of osteoporosis.

• Reduced exposure to sunlight
• An overactive thyroid gland
• A family history of osteoporosis
• Heavy drinking and smoking
• Long-term use of certain medicines, including epilepsy medicines

Some epilepsy medicines that can affect your bones

In 2009, the Medicines, Healthcare Products Regulatory Authority (MHRA) summarised various studies of people taking epilepsy medicines, who had a risk of broken bones. They advised that people taking the following older epilepsy medicines long-term were at risk of osteoporosis or broken bones.

Sodium valproate

Information about sodium valproate
The Medicines and Healthcare Products Regulation Agency (MHRA) have published some more detailed information about sodium valproate. If you are taking sodium valproate, or your doctor is considering prescribing sodium valproate for you the MHRA advise you to read this booklet along with the patient information leaflet. This is because they are advising that, if you are a woman capable of becoming pregnant your doctor should only prescribe sodium valproate if nothing else works for you.

There is very little research to show whether some of the newer epilepsy medicines can cause BMD problems. But a study looked at a group of 168 people who had taken epilepsy medicines for more than two years. All 168 people had their BMD measured, to see if they were risk of damage to their bones. The study found that as well as the older medicines listed above, people taking levetiracetam (Keppra) long-term had a high risk of their mineral bone density being lowered. This could make them higher risk for damaging their bones. The numbers in this study were very small, and more research needs to be done.

If you are worried about your epilepsy medicines affecting your bone health, speak to your doctor. Don’t stop taking your medicines, as this could cause you to have more seizures. 

Are your bones at risk?

The National Osteoporosis Society (NOS) has developed a questionnaire so that you can assess your individual risk of developing osteoporosis. If your answers suggest you need to take measures to protect your bones, you will be given that information at the end of the questionnaire. You can also print a copy of your results to show your doctor. If you are at high risk of developing osteoporosis, your doctor may refer you for a bone density scan, known as a DEXA scan.

To use the NOS questionnaire to check your risk of developing osteoporosis, go to nos.org.uk.

Being diagnosed with low bone density

If you are diagnosed with low BMD, it doesn’t necessarily mean you have a high risk of fracture. Ask your doctor to check all your risk factors for osteoporosis and broken bones. They can help you take positive steps to improve your bone health, which may include taking Vitamin D supplements.

Improving your bone health

The following is suggested by NHS Choices to help make your bones as healthy as possible. Doing these things will help your BMD, but won’t guarantee you won’t develop osteoporosis.

• Eat calcium-rich foods.
• Get your sunshine quota.
• Go easy on the protein.
• Quit smoking.
• Cut down the salt.
• Be active.
• Drink sensibly.
• Maintain a healthy weight.

To find out what each of these things mean, go to nhs.org.uk

Pay it forward

This resource is freely available as part of Epilepsy Action’s commitment to improving life for all those affected by epilepsy.

On average it costs £414 to produce an advice and information page – if you have valued using this resource, please text FUTURE to 70500 to donate £3 towards the cost of our future work. Terms and conditions. Thank you

We can provide references and information on the source material we use to write our epilepsy advice and information pages. Please contact our Epilepsy Helpline by email at helpline@epilepsy.org.uk.

Epilepsy Action would like to thank Dr Aza Abdulla, Consultant Physician, Princess Royal University Hospital, Bromley Hospitals NHS Trust, London for his contribution to this information. Dr Abdulla has declared no conflict of interest.

This information has been produced under the terms of The Information Standard.

  • Updated August 2013
    To be reviewed August 2016

Comments: read the 2 comments or add yours


It may be that bone loss is what is alleviating epileptic symptoms. The extra calcium released from the bone raises blood calcium levels which then lowers neuron excitability. AEDs accelerate the release but the body has its own mechanism for releasing calcium from the bone when blood levels are too low. This may explain the association of bone loss and epilepsy in general.

Submitted by Greg Marlow on

Hi Greg

Thank you for this information. We will hold it on file and speak with one of our medical advisors about it  when we next up date this information.


Epilepsy Action Advice and Information Team

Submitted by Diane@Epilepsy ... on